Researchers at the University of British Columbia have achieved a major advance in stem cell engineering by developing a reliable method to produce helper T cells from stem cells in a controlled lab environment. This breakthrough, detailed in the journal Cell Stem Cell, tackles a persistent obstacle in cell therapy production, making treatments more affordable […]
ADI-212 is a new type of immune cell therapy made from gamma delta T cells, the kind of immune cells that naturally go after tumors. These cells are specially engineered to attack PSMA-positive metastatic castration-resistant prostate cancer. The therapy has two smart upgrades. First, it carries a special version of IL-12, a powerful immune signal, […]
The KAIST team has introduced a highly innovative form of cancer immunotherapy that turns the body’s own macrophages into potent, targeted cancer killers directly inside solid tumours. Instead of the classic, laborious route of extracting immune cells from a patient, engineering them in a lab, expanding them, and reinfusing them, this approach reprograms macrophages already […]
A research team at the Korea Advanced Institute of Science and Technology (KAIST) has developed a new artificial intelligence model that could change how personalized cancer vaccines are designed. For decades, most cancer vaccine strategies have focused on training the immune system’s T cells to attack tumors quickly and directly, which can shrink tumors but […]
Researchers from Israel’s Weizmann Institute of Science have unveiled a promising immunotherapy strategy that targets drug-resistant cancers by exploiting the very genetic mutations responsible for treatment failure. The approach centers on a computational tool called SpotNeoMet, which scans large patient datasets to identify recurrent resistance mutations that generate neo-antigens, unique protein fragments displayed exclusively […]
In a previous article, cancer reversion was introduced as the idea that malignant cells can be pushed back toward a more normal, less aggressive state instead of simply being destroyed. That earlier discussion focused mainly on epigenetic plasticity, differentiation therapy, and microenvironmental modulation as ways to coax cancer cells into behaving more like healthy tissue. […]
Super-adjuvant nanoparticles are a new type of cancer vaccine that works much better than older versions. Scientists at the University of Massachusetts Amherst created them. Their main study came out in October 2025 in Cell Reports Medicine. These tiny particles fight cancer by waking up the body’s immune system in a smart way. They mix […]
The Japanese tree frog, Dryophytes japonicus, has become the source of a striking experimental cancer approach via a gut bacterium, Ewingella americana, that can completely eradicate colorectal tumors in mice. Amphibians and reptiles rarely develop cancer, so researchers systematically screened 45 bacterial strains from frogs, newts, and lizards; nine showed anti-tumor activity, but E. americana […]
A team of scientists in China has found a way to turn the same type of cells that cause allergies into a new kind of weapon against cancer. Their work suggests that the body’s fastest immune reaction, normally blamed for hives and asthma, could be redirected to wake up the immune system inside tumors and […]
AB-3028 represents a next-generation approach to solid-tumor CAR T therapy tailored to the unique challenges of metastatic castration-resistant prostate cancer. CAR T cells, transformative in hematologic malignancies, have struggled in solid tumors due to heterogeneous antigen expression, on-target off-tumor risks, suppressive cytokines like TGF-β, and chronic stimulation that drives exhaustion. AB-3028 was engineered to counter […]
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