A new preclinical study suggests that doxycycline, a widely used antibiotic, may help interfere with the process that allows prostate cancer cells to spread and grow in bone. The researchers identified acetylated KLF5 (Ac-KLF5) as an important driver of bone metastasis. This altered form of KLF5 appears to make prostate cancer cells more invasive and […]
Most cancer drugs attack something on the tumour cell: a receptor, an enzyme, a signalling pathway or a surface protein. TTX-MC138 takes a different approach. It is designed to inhibit microRNA-10b (miR-10b), a small regulatory RNA strongly associated with invasion, metastatic progression and survival of metastatic tumour cells. The idea is unusually ambitious: rather than […]
A promising study published this month in Science Advances introduces a promising “neuroimmunotherapy” nanocarrier called LipoNCs@pGSDMB, designed precisely for bone metastases like those in prostate cancer. This tiny, smart drug delivery system activates only in the high-oxidative-stress environment of bone tumors, fusing directly with cancer cell membranes to release its payload straight into the cell’s […]
Since FDA cleared PT-112 for a pivotal phase 3 trial in May 2025 (we talked about it here) following a successful end-of-phase-2 meeting, fresh insights illuminate why this novel platinum-based agent merits excitement for late-line metastatic castration-resistant prostate cancer (mCRPC). PT-112 stands apart from traditional platinums: its pyrophosphate structure drives osteotropism (high bone accumulation alongside […]
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