A University of Michigan study suggests that combining two types of drugs could offer a new approach to treating advanced, treatment-resistant prostate cancer. The research focused on tumors that have changed their identity through a process called transdifferentiation. These tumors can become more aggressive and may no longer respond well to standard treatments that target […]
A recent study is drawing attention for a surprising reason: sildenafil, the active ingredient in Viagra, may do more than treat erectile dysfunction. Researchers reported evidence that it could also make it harder for cancer cells to spread, by interfering with the cells’ ability to access cholesterol, which appears to be important for metastasis. The […]
A recent preclinical study points to a potentially important strategy for advanced prostate cancer: combining two already-known drugs to attack the disease from different angles at the same time. The work focused on metastatic castration-resistant prostate cancer, one of the hardest forms of prostate cancer to treat because it often adapts after standard hormonal therapies […]
Researchers have identified SIRT1 as a promising new target in neuroendocrine prostate cancer, a rare but highly aggressive subtype that often develops after standard hormone therapy stops working. The finding is important because this form of prostate cancer is especially hard to treat and tends to behave more aggressively than typical androgen-driven disease. The study […]
Telmisartan, a widely used blood pressure drug, has shown unexpected promise as a booster for cancer treatment. Preclinical research indicates that when telmisartan is combined with the PARP inhibitor olaparib, cancer cells accumulate more DNA damage and become more vulnerable to treatment, even if they do not carry the usual BRCA‑type DNA repair defects that […]
Orlistat is a well‑known weight‑loss drug that also blocks a key enzyme cancer cells use to make fats, and researchers have been trying to re‑use it against tumors for years. Recently a team developed a new way to deliver orlistat directly into prostate cancer cells by packing it inside tiny, engineered particles called Cys8E nanoparticles […]
A huge international team has just completed the largest study ever on how our genes control the levels of proteins circulating in our blood. The work, led by researchers at Queen Mary University of London and the Berlin Institute of Health, brings together data from more than 78,000 people across 38 cohorts worldwide and has […]
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