A Promising Drug Pair for Treatment-Resistant Prostate Cancer

A recent preclinical study points to a potentially important strategy for advanced prostate cancer: combining two already-known drugs to attack the disease from different angles at the same time. The work focused on metastatic castration-resistant prostate cancer, one of the hardest forms of prostate cancer to treat because it often adapts after standard hormonal therapies […]

Scientists Identify SIRT1 as a Driver of Neuroendocrine Prostate Cancer

Researchers have identified SIRT1 as a promising new target in neuroendocrine prostate cancer, a rare but highly aggressive subtype that often develops after standard hormone therapy stops working. The finding is important because this form of prostate cancer is especially hard to treat and tends to behave more aggressively than typical androgen-driven disease. The study […]

Telmisartan: A Familiar Blood Pressure Pill with New Potential in Cancer Therapy

Telmisartan, a widely used blood pressure drug, has shown unexpected promise as a booster for cancer treatment. Preclinical research indicates that when telmisartan is combined with the PARP inhibitor olaparib, cancer cells accumulate more DNA damage and become more vulnerable to treatment, even if they do not carry the usual BRCA‑type DNA repair defects that […]

Orlistat@Cys8E Nanoparticles: Remodeling Lipids to Kill Prostate Cancer

Orlistat is a well‑known weight‑loss drug that also blocks a key enzyme cancer cells use to make fats, and researchers have been trying to re‑use it against tumors for years. Recently a team developed a new way to deliver orlistat directly into prostate cancer cells by packing it inside tiny, engineered particles called Cys8E nanoparticles […]

Genetic Maps of Blood Proteins Open New Paths for Cancer Drug Repurposing

A huge international team has just completed the largest study ever on how our genes control the levels of proteins circulating in our blood. The work, led by researchers at Queen Mary University of London and the Berlin Institute of Health, brings together data from more than 78,000 people across 38 cohorts worldwide and has […]