Most radioligand therapies rely on a single molecular target. INN02 takes a different approach, combining two targets in the same molecule: fibroblast activation protein (FAP) and integrin αvβ3, both found in the tumour microenvironment. The same compound can be labelled with gallium-68 for PET imaging or lutetium-177 for therapy, creating a true theranostic platform. In […]
Most cancer drugs attack something on the tumour cell: a receptor, an enzyme, a signalling pathway or a surface protein. TTX-MC138 takes a different approach. It is designed to inhibit microRNA-10b (miR-10b), a small regulatory RNA strongly associated with invasion, metastatic progression and survival of metastatic tumour cells. The idea is unusually ambitious: rather than […]
A single infusion of a CRISPR-based therapy has significantly reduced attacks in patients with hereditary angioedema (HAE) in what appears to be the first successful Phase III trial of an in vivo gene-editing treatment. The findings, presented at a major European congress and published in the New England Journal of Medicine, mark a turning point […]
Scientists have developed a promising new CAR‑T cell therapy for osteosarcoma, the most common bone cancer in children, adolescents, and young adults, and the work carries a cautiously optimistic signal for other solid tumors, including metastatic prostate cancer. In a preclinical study, researchers at Case Western Reserve University and University Hospitals engineered T cells to […]
ALCO5 is a new way of building “smart” cancer drugs that combine an antibody with a powerful medicine in a single, targeted package. The aim is to hit cancer cells much harder while sparing as much healthy tissue as possible, and to do this with drug types that previously could not be used in these […]
Logic-gated DARPins are a promising new tool in cancer treatment that could make immunotherapy safer and more effective for hard-to-treat solid tumors. They work by only turning on immune cells called T cells when two specific markers are found together on cancer cells, preventing dangerous overactivation in healthy parts of the body. What makes them […]
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