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A new, user friendly way, to get information about current clinical trials available to prostate cancer patients.
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177Lu-PSMA-617 225Ac abiraterone abiraterone acetate ADC ai in healthcare antibody-drug conjugate apalutamide ATM B7-H3 bispecific antibody bone metastases bone metastasis BRCA BRCA2 cancer immunotherapy CAR-T CD3 clinical trial crispr darolutamide docetaxel drug repurposing enzalutamide EZH2 inhibitor HRR immunotherapy mcrpc metastatic hormone-sensitive prostate cancer mHSPC mRNA NEPC neuroendocrine prostate cancer oncolytic virus PARP1 PARP inhibitor Pluvicto prostate cancer protac PSMA radioligand therapy radiopharmaceuticals real-world data STEAP1 T-cell therapy
Latest Posts
- Newsletter 24/2026 June 14, 2026
- Phase 2 Trial for 61Cu-NU101 vs 18F-Piflufolastat in Metastatic Prostate Cancer June 11, 2026
- UPDATE: Memantine for Neuroendocrine Prostate Cancer, Early Efficacy Signals June 9, 2026
- BRCA-Altered mCSPC Progresses Faster on ARPIs: A Real-World Treatment Gap June 9, 2026
JMKX007129: A Next‑Generation AR‑NTD Inhibitor for Overcoming Resistance in mCRPC
/in Preclinical Research/by MaxJMKX007129 is a new small‑molecule drug that targets the N‑terminal domain (NTD) of the androgen receptor (AR) in prostate cancer. It is designed to overcome resistance seen with current AR‑ligand binding domain (LBD) inhibitors, which often stop working in castration‑resistant prostate cancer (CRPC) when AR develops mutations or produces splice variants like AR‑V7. JMKX007129 builds […]
AUTOTAC Degraders ATB‑238 and ATB‑239 Target AR and AR‑v7 in Advanced Prostate Cancer
/in Preclinical Research/by MaxAUTOTACs (Autophagy‑Targeting Chimeras), are molecules designed to force cancer cells to “clean up” and destroy the androgen receptor (AR), a key driver of prostate cancer growth and progression. The latest research on two second‑generation AR‑targeting AUTOTACs, ATB‑238 and ATB‑239, shows that these compounds can effectively degrade not only the normal AR but also its troublesome […]
²²⁵Ac‑RAX104: A Next‑Generation PSMA Alpha Radioligand for Advanced Prostate Cancer
/in Preclinical Research/by MaxRAX104 is a small molecule ligand designed specifically to target PSMA, the protein that is highly expressed on the surface of prostate cancer cells. When labeled with ²²⁵Ac, it forms a radioligand that combines the physical advantages of actinium‑225 (high linear energy transfer and a 10‑day half‑life) with a ligand engineered for better tumor retention. […]
HLX3902: A Trispecific T‑Cell Engager Rewiring the Immune Desert in Prostate Cancer
/in Immunotherapy, Preclinical Research/by MaxHLX3902 is a STEAP1×CD3×CD28 trispecific T‑cell engager developed as a potential first‑in‑class immunotherapy for prostate cancer. Prostate tumors are largely “cold” from an immunological standpoint. The microenvironment is immunosuppressive, T cells are scarce inside the tumor mass, and those that do infiltrate often burn out quickly after activation. Classical CD3‑only bispecific TCEs can force T […]
JZY3032 and Domain‑ALTeration Chimeras: A New Class of Proximity‑Based Therapeutics
/in Preclinical Research/by MaxChemical‑induced proximity (CIP) strategies have expanded the therapeutic toolbox by modulating protein–protein interactions, but classical approaches such as PROTACs and molecular glues often force unnatural pairings or stabilize existing interfaces, leading to variable or unpredictable effects. Domain‑ALTeration Chimeras (DALTACs) take a different path: instead of degrading targets or reinforcing native contacts, they selectively miswire endogenous […]
TBI‑001: A TRIB2‑Targeted Strategy to Counter Lineage Plasticity and Treatment‑Emergent Neuroendocrine Prostate Cancer
/in Preclinical Research/by MaxA new experimental drug called TBI‑001 targets a protein called TRIB2 in advanced prostate cancer that has become resistant to hormone therapy and starts acquiring neuroendocrine features. This is particularly relevant for treatment‑emergent neuroendocrine prostate cancer (t‑NEPC), a lethal subtype that arises after long‑term androgen‑receptor–targeted therapy, loses dependence on AR signaling, and adopts a neuroendocrine […]
A First‑in‑Class Dual AR‑V7/AR Molecular Glue Degrader for Metastatic Castration‑Resistant Prostate Cancer
/in Preclinical Research/by MaxMost prostate cancer treatments today target the part of the AR protein that binds hormones, known as the ligand‑binding domain or LBD. At first these drugs like enzalutamide and abiraterone can shrink tumors or slow progression, but over time the cancer adapts and becomes resistant. This adaptation is a major reason why men with mCRPC […]
Soon to Be Phase 1 Trial: FX‑111, A Selective ARon Degrader with the Potential to Rethink Androgen Deprivation in Prostate Cancer
/in Clinical Trial, Metastatic, Phase 1/by MaxA novel approach to targeting androgen receptor signaling in prostate cancer is emerging with FX‑111, an experimental degrader that selectively removes the hormone‑bound, transcriptionally active form of the receptor known as ARon. In metastatic castration‑resistant prostate cancer (mCRPC), the androgen receptor remains a central driver in the vast majority of cases, yet resistance to current […]