Insilico Medicine has nominated ISM3830, a potentially best-in-class oral CBLB inhibitor discovered through its proprietary Chemistry42 AI platform, as a preclinical candidate for advanced cancer immunotherapy. This novel molecule targets Casitas B-lineage lymphoma-b (CBLB), an intracellular E3 ubiquitin ligase that acts as a master negative regulator of T-cell and natural killer (NK) cell activation, distinct […]
The modern small‑molecule rarely acts through a single, invariant target, and DeepTarget is a new computational framework that embraces this reality by mapping both direct and indirect anti‑cancer mechanisms across diverse cellular contexts. Developed by researchers at Sanford Burnham Prebys and collaborators, DeepTarget integrates large‑scale drug viability screens, genome‑wide CRISPR knockout data, and matched omics […]
At the ESMO Congress 2025 held in Berlin, artificial intelligence demonstrated a pivotal role in reshaping cancer treatment through novel biomarker applications. Studies presented at this event showed how AI models analyzing pathology images, imaging data, and genomic profiles can improve predictions of patient responses to therapies. For example, in metastatic colorectal cancer, AI identified […]
A collaboration between Yale University and Google DeepMind has led to a rare scientific milestone: an artificial intelligence system that not only analyzed biological data but also generated and experimentally validated a new hypothesis for cancer treatment. Announced on October 15, 2025, the 27‑billion‑parameter foundation model, called Cell2Sentence‑Scale 27B, was developed to interpret single‑cell RNA […]
A new AI platform developed by researchers at the Technical University of Denmark and the Scripps Research Institute has dramatically accelerated the design of specialized protein molecules called “minibinders” to enhance cancer immunotherapy. Normally, T cells recognize cancer cells by detecting protein fragments (peptides) presented on their surface by molecules known as pMHCs, but harnessing […]
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