A blood test taken before starting treatment could help identify men with metastatic hormone-sensitive prostate cancer (mHSPC) who are at greater risk of developing treatment resistance early. We have already discussed the importance of ctDNA after treatment in a previous article, but this new study looks at its potential value even before treatment begins. A […]
A new prospective clinical study suggests that radium-223 may change the immune environment of prostate cancer bone metastases in a way that makes subsequent immunotherapy less effective. The study included 28 men with metastatic castration-resistant prostate cancer (mCRPC) and predominantly bone metastases. Patients received radium-223, with six injections planned at four-week intervals. Researchers wanted to […]
A simple blood test normally associated with colorectal cancer could provide additional information about how men with metastatic castration-resistant prostate cancer fare after 177Lu-PSMA-617 therapy. A new prospective study of 142 patients found that elevated carcinoembryonic antigen (CEA) before treatment was independently associated with shorter progression-free and overall survival. The finding does not mean that […]
A newly registered phase 1 trial is taking an interesting approach to one of the limitations of T-cell engagers in prostate cancer: rather than simply trying to make them more powerful, it will test whether a second immune signal can make their activity more durable. The trial will evaluate JANX007 together with the new drug […]
CRISPR can precisely alter DNA, but using it against cancer faces a fundamental problem: how do you deliver the genome-editing machinery to tumour cells without also editing healthy tissue? A newly published review proposes that aptamers, small synthetic DNA or RNA molecules capable of recognising specific cell-surface proteins, could provide part of the solution, guiding […]
A newly published study has introduced an interesting variation on antibody-drug conjugates (ADCs) for advanced prostate cancer: instead of simply delivering a toxic payload to cancer cells, the treatment is designed to help the immune system recognise what remains. The experimental ADC targets STEAP1, a cell-surface protein highly expressed in prostate cancer and already being […]
A new antibody-drug conjugate has received clearance to enter clinical trials in China with a double strategy for prostate cancer: instead of targeting PSMA or STEAP1, ICP-B381 targets both. The experimental bispecific ADC combines a humanised antibody recognising PSMA and STEAP1 with a proprietary cytotoxic payload connected through an irreversible linker. Both proteins are strongly […]
Two important scientific developments, published last week, offer a glimpse of where prostate cancer research could be heading, even though both remain firmly in the experimental or preclinical arena. The first comes from Adelaide University, where researchers have developed “smart” lipid nanoparticles designed to reprogramme tumour-associated macrophages, immune cells that cancers can exploit to suppress […]
Many proteins that drive cancer are considered “undruggable” because they lack the pockets that conventional drugs need to bind and block them. A new approach in prostate cancer attempts to bypass this problem: instead of inhibiting a cancer-driving protein, make the cell destroy it. Researchers have developed a protein degrader (against an undisclosed protein) believed […]
LAST WEEK TODAY! A summary of what was published on ProstateWarriors.com during the past week Hello fellow warriors! This week is focused mainly on clinical research. Stay strong and fight on! As usual, we also have a podcast if you prefer to listen to the newsletter, you can find it HERE. Clinical Research Phase 1 Trial: IL-18–Armored STEAP1 […]
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