A simple blood test normally associated with colorectal cancer could provide additional information about how men with metastatic castration-resistant prostate cancer fare after 177Lu-PSMA-617 therapy. A new prospective study of 142 patients found that elevated carcinoembryonic antigen (CEA) before treatment was independently associated with shorter progression-free and overall survival. The finding does not mean that […]
A new cohort study published in JAMA Network provides some of the most detailed evidence to date on how the type of fat men eat after a prostate cancer diagnosis relates to long-term survival. The analysis, based on 4,884 participants in the Health Professionals Follow-Up Study followed for a median of 12.8 years, shows that […]
A new clinical study is testing a smarter way to give radiation after prostate surgery. The approach, called daily adaptive radiotherapy, uses artificial intelligence to adjust the treatment plan every day based on how the patient’s anatomy looks at that moment. Early results from the first 42 patients in the DART-PHASER trial suggest the method […]
A decade after diagnosis, most men with localized prostate cancer are far more likely to die of something else than of their cancer, regardless of whether they choose surgery, radiation, or active surveillance. This is the central message of the long-term follow-up from the CEASAR study, a large, prospective, observational population-based U.S. cohort that enrolled […]
Research presented during ASCO GU 2026, showed that germline DDR variants are common enough in metastatic prostate cancer to matter clinically, but their impact is highly gene-specific. In this 3,005-patient cohort, about 9% carried a germline DDR variant, and the study was especially important because it assessed both small variants and structural variants across 31 […]
A recent study, published on Nature, looked at a question that matters just as much as prostate cancer risk: why do some tumors stay quiet while others become life-threatening after diagnosis? The researchers searched for genes whose activity might be linked to survival, not just to the chance of developing the disease. To do this, […]
Recent real-world data clarify how homologous recombination repair (HRR) alterations, especially BRCA1/2 mutations, affect outcomes in metastatic castration-sensitive prostate cancer (mCSPC) treated with androgen receptor pathway inhibitors (ARPIs). In a US cohort of 745 patients, overall differences in time-to-next-treatment (TTNT) and time-to-castration resistance (TTCR) were modest between patients without HRR alterations and those with non-BRCA […]
Relugolix (Orgovyx), the first oral androgen deprivation therapy approved for advanced prostate cancer, continues to show consistent performance in real-world settings. New data from the OPTYX study, a prospective observational analysis, provide further evidence on testosterone suppression, recovery, and PSA control in routine clinical practice. The study included 999 patients, predominantly with nonmetastatic disease and […]
A 2026 study published in Clinical Cancer Research has pinpointed B7-H3 as a standout therapeutic target for prostate cancer, offering hope against the disease’s toughest forms. The work analyzed tissue from prostate cancer patients across the full spectrum, from hormone-sensitive and castration-resistant to neuroendocrine and “double-negative” subtypes, revealing B7-H3’s consistent, broad expression. This uniformity stands […]
A new observational study of more than 8,000 prostate tumors shows that B7‑H3 (CD276) expression helps shape prognosis and could open new paths for targeted therapies. Researchers analyzed 8,157 prostate cancer samples with matched DNA and RNA data, stratifying them by tissue site, hormone‑sensitivity status, and self‑reported race, then examined how B7‑H3 levels related to […]
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