A retrospective analysis from the Oxford GPS-ProMPT study provides further evidence that genomic profiling can reveal which prostate cancers are truly aggressive and which are not, even when clinical features suggest otherwise. The study evaluated the 17-gene Genomic Prostate Score (GPS mdx) in 409 patients managed with active surveillance, radical prostatectomy, or radiotherapy with androgen […]
A regional retrospective study covering 2011 to 2025 suggests that a more intensive radiotherapy strategy may improve survival in selected patients with prostate cancer and bone metastases. The analysis included 246 consecutive men who received 347 radiotherapy courses and asked whether treating bone lesions more aggressively, together with prostate-directed radiotherapy, could translate into longer overall […]
Using data from the international ARON-3 real-world study, investigators performed a retrospective head-to-head comparison of darolutamide- and abiraterone-based triplet therapy in patients with metastatic hormone-sensitive prostate cancer. The comparison included 247 patients treated with darolutamide plus docetaxel plus androgen deprivation therapy or abiraterone plus docetaxel plus androgen deprivation therapy across 37 institutions in 14 countries. […]
A recent study, published on Nature, looked at a question that matters just as much as prostate cancer risk: why do some tumors stay quiet while others become life-threatening after diagnosis? The researchers searched for genes whose activity might be linked to survival, not just to the chance of developing the disease. To do this, […]
A major advancement in metastatic hormone-sensitive prostate cancer has emerged from the ENZAMET trial: analysis using the Decipher genomic classifier shows that men with very high-risk tumor profiles benefit significantly from adding docetaxel to standard hormone therapy. Patients with a Decipher score above 0.85 who received the triplet regimen (ADT plus enzalutamide plus docetaxel) had […]
Recent real-world data clarify how homologous recombination repair (HRR) alterations, especially BRCA1/2 mutations, affect outcomes in metastatic castration-sensitive prostate cancer (mCSPC) treated with androgen receptor pathway inhibitors (ARPIs). In a US cohort of 745 patients, overall differences in time-to-next-treatment (TTNT) and time-to-castration resistance (TTCR) were modest between patients without HRR alterations and those with non-BRCA […]
Therapy intensification in metastatic prostate cancer has expanded the repertoire of combination regimens, but it remains unclear which patients truly benefit from adding upfront docetaxel to an androgen receptor pathway inhibitor (ARPI) based doublet. A large real world cohort study using the U.S. based Patient360 Prostate dataset, which aggregates de identified electronic health records, linked […]
Agents such as abiraterone and darolutamide have demonstrated significant survival benefits in randomized clinical trials, yet direct comparative evidence between these therapies, particularly in the pre-chemotherapy setting, remains notably absent. A recent retrospective cohort analysis leveraging the TriNetX database attempts to address this gap by comparing real-world outcomes in patients treated with ADT plus either […]
Researchers in Japan have found that muscle “quality,” not just size, is linked to how long men with non‑metastatic castration‑resistant prostate cancer (nmCRPC) live, even when they are treated with androgen receptor signaling inhibitors. The study analyzed 344 men using standard CT scans to measure muscle quantity and the amount of fat inside the muscle, […]
A new analysis reports the development of a simple clinical score that may help physicians better identify which men are most likely to benefit from treatment with cabazitaxel after disease progression on earlier therapies. The work, based on a post-hoc analysis of the CABASTY study and validated in two major phase-3 trials, suggests that survival […]
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