Bavdegalutamide Plus Abiraterone in Metastatic Prostate Cancer: Phase Ib Safety and Activity Results

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Bavdegalutamide (ARV-110) is an oral androgen receptor degrader designed to address resistance to androgen-receptor–targeted therapy in metastatic prostate cancer. In this phase 1b study, it was combined with abiraterone in patients whose disease was progressing on abiraterone, with the goal of testing safety, pharmacokinetics, and early signs of antitumor activity. The trial enrolled 45 patients, […]

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Phase 1 RIALTO Trial: Radiotherapy for Metastatic Prostate Cancer With Incomplete Hormone Response

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The RIALTO trial challenges decades of oncology dogma that treating the prostate becomes irrelevant once cancer spreads. For patients with de novo metastasized prostate cancer who show incomplete PSA-response (PSA >0.2 ng/ml after six months of combined ADT+ARPI), the prostate may function as a persistent tumor reservoir continuously seeding metastases. Local radiotherapy to the prostate […]

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UPDATE: OncoACP3‑DOTA, First‑in‑Human Therapeutic Signal Beyond PSMA

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OncoACP3‑DOTA is a small‑molecule ligand directed at prostatic acid phosphatase (ACP3, also historically called PAP), a membrane‑bound phosphatase that is highly specific to the prostate, with only weak expression in normal tissues such as kidney. Preclinical work showed that ACP3 is retained in many prostate tumors, including lesions with low or absent PSMA expression, and […]

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Complete Response to Pembrolizumab in a Metastatic, Castration‑Resistant Prostate Cancer Survivor

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A remarkable case published in Annals of Internal Medicine: Clinical Cases highlights a man with metastatic, castration‑resistant prostate cancer who achieved a complete and durable response to pembrolizumab after exhausting multiple standard therapies. The patient had previously received abiraterone‑based treatment followed by chemotherapy, and then olaparib, all of which he had progressed on, leaving him […]

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