For decades, PSA has been the main biomarker used to monitor prostate cancer. It is inexpensive, accessible, and clinically familiar, but it does not always reflect what is happening inside metastatic tumors. PSA production is linked to androgen-receptor signaling, meaning that treatment-resistant or neuroendocrine-like tumor clones may continue to grow without producing a corresponding PSA […]
Bipolar androgen therapy (BAT) is a paradoxical treatment strategy for metastatic androgen pathway modulation–resistant prostate cancer (mAPMR), formerly known as metastatic castration‑resistant prostate cancer (mCRPC), that replaces continuous androgen suppression with cyclical, supraphysiologic testosterone exposure, aiming to exploit the tumor’s dependence on an overactive androgen receptor (AR). The approach was pioneered by Samuel Denmeade and […]
The Prostate Cancer Working Group 4 (PCWG4), published in February 2026, introduces patient-centric updates to advanced prostate cancer trial design, shifting from PCWG3’s clinical state model to a therapeutic indication framework. PCWG4 replaces outdated terms like “castration-resistant prostate cancer” (CRPC), “non-metastatic castration-resistant prostate cancer” (nmCRPC), “metastatic castration-resistant prostate cancer” (mCRPC), “hormone-sensitive prostate cancer” (HSPC), and […]
The WOLVERINE study is a major analysis combining patient data from seven phase 2 trials, published in The Lancet Oncology. It looked at 574 men with oligometastatic prostate cancer (meaning up to five spots of cancer spread), mostly to bones or lymph nodes. Six of those trials (472 men) directly compared adding metastasis-directed therapy (MDT) […]
In a recent presentation, Dr. Oliver Sartor highlighted Lead-212 (Pb-212) as a promising next step in precision radioligand therapy for metastatic castration-resistant prostate cancer. Developed by the same Oslo-based team that introduced Radium-223, Lead-212 is being studied in the ARTISAN (AB001) trial and represents a significant evolution in alpha-emitting radiopharmaceuticals. Its defining features are a […]
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