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A new, user friendly way, to get information about current clinical trials available to prostate cancer patients.
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177Lu-PSMA-617 abiraterone abiraterone acetate ADC ADT ai in healthcare antibody-drug conjugate apalutamide ATM B7-H3 bispecific antibody bone metastases bone metastasis BRCA BRCA2 cancer immunotherapy CAR-T CD3 clinical trial crispr darolutamide docetaxel drug repurposing drug resistance enzalutamide EZH2 inhibitor HRR immunotherapy mcrpc mHSPC mRNA NEPC neuroendocrine prostate cancer oncolytic virus PARP1 PARP inhibitor Pluvicto prostate cancer protac PSMA radioligand therapy radiopharmaceuticals real-world data STEAP1 T-cell therapy
Latest Posts
- Newsletter 43/2026 October 25, 2026
- Phase 3 DASL-HiCaP: Darolutamide Reduces Metastasis Risk in High-Risk Prostate Cancer October 24, 2026
- UPDATE: PROTEUS Substudy Shows Improved Event-Free Survival With Perioperative Apalutamide October 24, 2026
- UPDATE: Bavdegalutamide Shows Stronger Activity in Prostate Cancers With Specific AR Mutations October 23, 2026
Zanzalintinib After Pluvicto in Chemo‑Naïve mCRPC
/in Clinical Trial, Metastatic, Phase 2/by MaxZanzalintinib is being tested after Pluvicto (177Lu-PSMA-617) in metastatic castration‑resistant prostate cancer (mCRPC) because it targets several escape routes tumors use once they have survived PSMA‑directed radioligand therapy and prolonged AR pathway blockade. Pluvicto delivers beta radiation to PSMA‑expressing cells, inducing DNA damage and tumor cell death, but progression still occurs and is often driven […]
UPDATE: ABBV-969 Shows Very Promising rFPS in mCRPC
/in Clinical Trial, Metastatic, Phase 1/by MaxABBV-969 is a dual-target antibody-drug conjugate targeting PSMA and STEAP1, data about its radiographic progression-free survival data have just been released, confirming a median rPFS of approximately 15 months in heavily pretreated metastatic castration-resistant prostate cancer. The study demonstrates a signal far exceeding the 4- to 5-month rPFS historically seen with cabazitaxel in the same […]
CD46 ImmunoPET in mCRPC: A New Theranostic Axis Beyond PSMA
/in Clinical Trial, Metastatic, Phase 1/by MaxCD46 is a cell‑surface protein that stays highly expressed in aggressive, late‑stage prostate cancer, including PSMA‑low, AR‑negative and neuroendocrine variants. That means CD46 immunoPET can still “see” and quantify disease that PSMA PET misses, and can guide CD46‑targeted therapies in exactly those PSMA‑low/negative patients who respond poorly to PSMA‑directed radioligand therapy. Using the human antibody […]
The PROTEUS Trial: Perioperative Apalutamide Shows Positive Results for Prostate Cancer
/in Clinical Trial, Non-Metastatic, Phase 3/by MaxThe PROTEUS phase 3 trial, published in the New England Journal of Medicine, shows that adding perioperative apalutamide to androgen-deprivation therapy significantly improves outcomes for men with high-risk localized or locally advanced prostate cancer undergoing radical prostatectomy. The international trial randomized 2,109 patients to six cycles of ADT plus apalutamide (240 mg daily) or ADT […]
VECTRA-01 Phase 3 Trial Tests Alpha-Emitting AZD2265 in PSMA-Positive mCRPC
/in Clinical Trial, Metastatic, Phase 3/by MaxA pivotal Phase 3 trial called VECTRA-01 has launched to evaluate AZD2265 (²²⁵Ac-PSMA-I&T), an alpha-emitting radioligand therapy targeting PSMA-positive metastatic castration-resistant prostate cancer. The study began in May 2026, enrolling approximately 670 participants across 90 global sites, with recruitment currently active at select locations. The trial’s primary objective is to demonstrate superiority over standard of […]
Zanzalintinib for Metastatic Castration-Resistant Prostate Cancer
/in Clinical Trial, Metastatic, Phase 2/by MaxZanzalintinib is a new investigational drug showing activity in metastatic castrate-resistant prostate cancer (mCRPC), particularly in patients with soft tissue or visceral metastases who have progressed on prior treatment. A single-arm Phase II trial is evaluating whether zanzalintinib is effective for this difficult-to-treat population. Participants can stay in the study for up to 24 months […]
The MOMENT Trial: Mevrometostat Plus Enzalutamide in Post‑ARPI, Pre‑Abiraterone mCRPC
/in Clinical Trial, Metastatic, Phase 2/by MaxMevrometostat is an oral EZH2 inhibitor being developed to overcome resistance to androgen‑receptor–targeted therapy in prostate cancer. In tumors, EZH2 helps switch off tumor‑suppressor genes and supports androgen‑independent growth and lineage plasticity, changes that are strongly linked to progression on drugs like enzalutamide. Adding an EZH2 inhibitor to continued AR blockade is meant to “re‑discipline” […]
Phase 3 CaBRA Trial: Adding Carboplatin for mHSPC With BRCA Mutations or Neuroendocrine Phenotype
/in Clinical Trial, Metastatic, Phase 3/by MaxIn the phase 3 CaBRA trial, carboplatin is added to the docetaxel-based chemotherapy backbone used with lifelong ADT (androgen deprivation therapy) and darolutamide, creating a quadruple-intensification therapy for a small but very high-risk subgroup of metastatic castration-sensitive prostate cancer. The trial focuses on tumors with either BRCA alterations or neuroendocrine differentiation, two features that are […]