A new analysis of the PRINCE clinical trial suggests that combining blood-based ctDNA testing with PSMA PET could help identify which men with metastatic castration-resistant prostate cancer (mCRPC) are most likely to respond to Lu-177 PSMA plus immunotherapy. PRINCE was a multicentre Phase 1/2 trial involving 37 men with mCRPC. Patients received up to six […]
An exploratory post hoc analysis of the international PEACE‑3 trial adds a compelling biomarker layer to the already positive story of combining radium‑223 with enzalutamide in men with bone‑metastatic, castration‑resistant prostate cancer. The parent study, a phase 3 randomised trial in asymptomatic or mildly symptomatic metastatic castration‑resistant prostate cancer (mCRPC) with bone metastases, had already […]
At the 2026 American Urological Association (AUA) Annual Meeting, researchers showed that radiographic progression‑free survival (rPFS), the time from treatment start until scans show clear cancer progression or death, is a strong and meaningful reflection of overall survival in men with metastatic castration‑resistant prostate cancer (mCRPC). Using individual‑patient data from the large TALAPRO‑2 trial, they […]
In a detailed review of two large clinical trials called ARCHES and PROSPER, doctors found that some patients experienced cancer growth visible on scans (known as radiographic progression) without seeing the usual rise in PSA blood levels, a key marker doctors often track. This mismatch highlights why regular imaging tests might be just as crucial […]
A recent post hoc analysis of the phase 3 EMBARK trial in high‑risk biochemical recurrent prostate cancer has generated considerable interest because it suggests that durable, long‑term PSA control can occur even after testosterone has fully recovered to eugonadal levels, challenging the conventional assumption that hormonal suppression must be continuous to maintain remission. The analysis […]
The ARASENS trial, a large phase 3 study, investigated the impact of adding darolutamide, a novel androgen receptor inhibitor, to the standard treatment of androgen-deprivation therapy (ADT) and docetaxel chemotherapy in patients with metastatic hormone-sensitive prostate cancer (mHSPC). A recent subgroup analysis focused on whether the benefits of this combination extend across age groups. In […]
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