Orlistat is a well‑known weight‑loss drug that also blocks a key enzyme cancer cells use to make fats, and researchers have been trying to re‑use it against tumors for years. Recently a team developed a new way to deliver orlistat directly into prostate cancer cells by packing it inside tiny, engineered particles called Cys8E nanoparticles […]
Researchers at Roswell Park Comprehensive Cancer Center have identified a critical vulnerability in how prostate cancers escape standard hormonal therapy. The study reveals that when androgen receptor signaling is suppressed by ADT or AR pathway inhibitors, cancer cells compensate by ramping up BCL-2, an anti-apoptotic protein that helps them survive treatment. The findings suggest that […]
A new CRISPR system recently published in Nature could change how we think about selectively eliminating cancer cells without touching healthy tissue. Instead of using the classic Cas9 to edit DNA, researchers have repurposed Cas12a2, an enzyme that first binds to a specific RNA sequence and then unleashes a wave of DNA destruction across the […]
Antibody–drug conjugates (ADCs) have transformed therapy in several malignancies, but in advanced prostate cancer they have mostly been evaluated for direct tumor cytotoxicity, with little attention to immune mechanisms that might underpin durable responses. A recent study introduces a new STEAP1‑targeted ADC platform built on vandortuzumab, an antibody directed at six‑transmembrane epithelial antigen of the […]
A huge international team has just completed the largest study ever on how our genes control the levels of proteins circulating in our blood. The work, led by researchers at Queen Mary University of London and the Berlin Institute of Health, brings together data from more than 78,000 people across 38 cohorts worldwide and has […]
GX-BP1, a bioPROTAC-based SOX2 degrader, selectively targets SOX2, an undruggable protein, for ubiquitin-proteasome elimination, overcoming limitations of prior inhibition strategies. In preclinical models, GX-BP1 monotherapy delivered approximately 70% tumor growth inhibition, while combinations with agents like carboplatin/paclitaxel achieved 87-96% inhibition and near-complete tumor suppression at optimal doses. Notably, GX-BP1 paired with osimertinib eradicated cancer stem […]
Prostate cancer treatments have hit a wall with castration-resistant cases, where tumors keep growing despite hormone blockers targeting the androgen receptor’s stable parts. A new study from University of British Columbia and BC Cancer researchers published on Nature cracks that open by hitting the receptor’s “undruggable” intrinsically disordered transactivation domain (NTD/TAD), the flexible region that […]
A new study in Nature Biotechnology describes a DNA-based drug system that can turn on only when it finds the right combination of markers on a cancer cell. This matters because many cancer drugs are powerful but also damage healthy tissue, so the main challenge is not only killing the tumor, but doing it with […]
Adoptive transfer of chimeric antigen receptor (CAR) T cells has worked well in some blood cancers, but it has been much less effective in solid tumors like prostate cancer. One reason is the strong cytokine release and strong immune suppression in the tumor area. A new study has designed a PSMA‑targeted CAR that uses CD16A, […]
For prostate cancer patients with low expression of PSMA or with neuroendocrine prostate cancer or NEPC (a population growing in size precisely because better treatments are forcing tumors to adapt), a new preclinical study offers a credible precision-targeted strategy: a radiotheranostic pair built on the CEACAM5 surface antigen that produced complete tumor responses in every […]
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