A recent study is drawing attention for a surprising reason: sildenafil, the active ingredient in Viagra, may do more than treat erectile dysfunction. Researchers reported evidence that it could also make it harder for cancer cells to spread, by interfering with the cells’ ability to access cholesterol, which appears to be important for metastasis. The […]
UCLA researchers have reported a promising way to improve antibody-drug conjugates, or ADCs, in metastatic castration-resistant prostate cancer, a disease that remains difficult to control once it stops responding to hormone therapy. Their work suggests that pairing ADCs with a drug that blocks BCL-XL can make prostate cancer cells more vulnerable, leading to greater cell […]
KAIST has reported a new cancer-fighting nanoparticle platform that combines two powerful ideas into one system: helping the immune system notice cancer cells and delivering gene therapy directly into those cells. The basic concept is simple. Instead of only trying to poison or block a tumor from the outside, the nanoparticle makes the cancer cell […]
Researchers at USC have found that prostate cancer cells may rely on a 3D network of DNA “switches”, called enhancers, to keep cancer genes turned on. Enhancers are not genes themselves; they are stretches of DNA that help control when nearby or distant genes are active and how strongly they are expressed. In this study, […]
Prostate cancer usually responds poorly to immunotherapy because the tumor hides from the immune system, earning the label of an “immune‑cold” cancer. A new RNA‑targeted CRISPR technology developed at Duke University School of Medicine and collaborating institutions re‑exposes these tumors to immune attack in mice by restoring a key protein complex on cancer cells that […]
A new preclinical study shows that radioligand therapy (RLT) can directly enhance CAR‑T cell efficacy in metastatic castration-resistant prostate cancer (mCRPC), addressing two major barriers: antigen heterogeneity and an immunosuppressive tumor microenvironment (TME). Researchers combined 177Lu‑PSMA‑617 (Pluvicto) with PSCA-targeted CAR‑T cells in sequence (RLT → cyclophosphamide → CAR‑T). Compared to either treatment alone, the combination […]
A recent study published in Small presents a novel way to treat bone metastases by combining nanotechnology, ultrasound, and immune activation into a single strategy. While the science behind it is complex, the concept is simple: create tiny particles that travel to bone tumors and, when activated by ultrasound, generate a highly localized anti-cancer effect. […]
Umeå University reports a novel fully human monoclonal antibody that blocks oncogenic signaling through the TGF‑β receptor I (TβRI), producing striking inhibition of both tumor growth and metastatic spread in aggressive prostate cancer models, according to a study published in Signal Transduction and Targeted Therapy. The antibody is composed entirely of human proteins, reducing immunogenicity […]
A novel therapeutic strategy combining PARP inhibition with selective T-cell receptor β chain activation is showing promising potential to overcome immune resistance in metastatic castration-resistant prostate cancer (mCRPC). This approach pairs olaparib, a well-established PARP inhibitor, with a bifunctional T-cell agonist (STAR0602) designed to selectively expand specific T-cell subsets through targeted delivery of interleukin-2. Prostate […]
For years, advanced prostate cancer has been the textbook example of an “immunologically cold” tumor: it doesn’t provoke a strong immune response, carries few mutations that help the immune system recognize cancer, and is packed with cells that actively suppress immunity. Because of this, immune checkpoint inhibitors have largely failed in this disease. Against this […]
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